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It was confirmed that the third film based on Dan Brown's Robert Langdon series. Tom Hanks returns back to be the main protagonist of the movie. Tom Hanks, who played Robert Langdon in the first two films based on Brown’s novels, The Da Vinci Code and Angels & Demons, is attached to be the star once again.

Following the worldwide successes of The Da Vinci Code which grossed $758 million worldwide in 2006 and Angels & Demons with $486 million in 2009, which were both based on Dan Brown's novels, starred Tom Hanks as Robert Langdon and produced and directed by Ron Howard, Columbia Pictures began production on a film adaptation of The Lost Symbol. Hanks and Howard were expected to return for the film adaptation of The Lost Symbol, along with the franchise's producers Brian Grazer and John Calley. Sony Pictures eventually hired three screenwriters for the project, beginning with Steven Knight and then hiring Dan Brown himself. In March of 2012, Danny Strong was also hired to collaborate on the adaptation.

According to a January 2013 article in the Los Angeles Times the final draft of the screenplay was due sometime in February, with pre-production expected to start in the mid-2013. In July 2013 Sony Pictures announced they would instead adapt Inferno for a December 18, 2015 release date with Ron Howard as director, David Koepp adapting the screenplay and Tom Hanks reprising his role as Robert Langdon.

In Inferno, which was published in May by Doubleday, Langdon is out to stop a threatening worldwide plague, following clues in Dante’s The Divine Comedy that take him to Florence and Venice, Italy.

Sony, which holds the film rights to the novels, began developing a film version of another of Dan Brown’s Langdon books, The Lost Symbol, but it now appears that Inferno will move forward first.